Use Pediatric Lexi-comp (up to date) as gold standard

DRUG NAME

DOSE

FREQUENCY

MAX DOSE

COMMENTS

Acyclovir

20 mg/kg/dose

10-15 mg/kg/dose

Q 8 hrs

 

20 mg/kg/dose for 3 mos-12yr

10-15mg/kg/dose for >12 yr

Ampicillin

100-400 mg/kg/day

÷ Q 6 hr

2 gm/dose

 

Amp/Sulbactam (Unasyn)

100-300 mg/kg/day

÷ Q 6 hr

2 gm/dose Amp

Express as Ampicillin component

Abelcet

5 mg/kg/day

Daily

 

Liposomal ampho B

Caspofungin

50-70 mg/m2

     

Cefazolin

20-25 mg/kg/dose

Q 8 hr

1 gm/dose

 

Cefepime

50 mg/kg/dose

Q 8 hr

Q 12 meningitis/CF

2 gm/dose

 

Ceftriaxone

50-100 mg/kg/day

Daily or ÷ Q 12 hr

2 gm/dose

100 mg/kg/d ÷ Q 12 hr for

meningitis

Clindamycin

10 mg/kg/dose

Q 8 hr or Q 6 hr

900 mg Q 8

 

Fluconazole

6-12 mg/kg/day

3-6 mg/kg/day

Daily

 

High dose for disseminated infections (12mg/kg/d)

Gentamicin

2.5 mg/kg/dose

Q 8 hr or Q 12 hr

Or based on troughs

 

Q 8 hr for normal kidneys,

Q 12 if < 1 mos

Dose per trough for renal failure

Meropenem

20 mg/kg/dose

Q 8 hr

1 gm/dose

Adjust for renal failure

Metronidazole

30 mg/kg/day

÷ Q 6 hr

 

PO is best route if able

Nafcillin

50-200 mg/kg/day

÷ Q 6 hr

2 gm/dose

Better if used centrally

Pip-Tazobactam (Zosyn)

50-75 mg/kg/dose

Q 6 hr

4 gm Piperacillin

Express as Piperacillin component

Vancomycin

15 mg/kg/dose

Q 6, 8 ,12 hrs or by troughs

1 gm/dose

Q 8 hr normal kidneys, Q 6 hr meningitis, Q 12 hr if < 1 month, Per trough for renal failure