Drug Dose (IV) Comment
Dexmedetomidine Bolus 0.5–1 mcg/Kg
over 10 minutes
Infusion: 0.25–1 mcg/
Avoid in patients with
heart block
Etomidate 0.3 mg/Kg/dose Avoid in septic shock
Adrenal suppression
Fentanyl 1 mcg/Kg/dose IV
q 30–60 minutes
Max dose: 300 mcg total
Continuous: 1 mcg/Kg/hr
Rigid chest with rapid
Ketamine 1 mg/Kg/dose (consider
with asthma)
Lorazepam 0.05–0.1 mg/Kg/dose q
4–6 hours Max dose: 4 mg
Midazolam 0.1 mg/Kg Avoid in hemodynamically
unstable patient
Morphine 0.1– 0.15 mg/Kg IV
q 3–4 hours
10 –30 mcg/Kg/hr
Ventilated patients may
receive larger doses, more
frequent intervals
Avoid in asthma patients
Pentobarbital 1–3 mg/Kg (max 100
mg) –– sedation
10–15 mg/Kg load (< 5
mg/Kg/hr), then 1–5 mg/
Kg/hr–– therapeutic coma
Avoid in hemodynamically
unstable patient
Propofol 25–100 mcg/Kg/min
(short term use only)
Avoid in hemodynamically
unstable patient